The number of proliferating and apoptotic cells, the mucosal mucus and prostaglandin e 2 pge 2 level were also determined. The results of the current research revealed that following fed the rats with biochanin a the protein concentration preserved in the homogenate stomach tissue. Gastric ulcers were induced by absolute ethanol 5 mlkg, i. Ulcer prevention effect of 3,4,5tihydroxyn02methyl. Macroscopic appearance of the gastric mucosa in hclethanol induced gastric ulcer in rats. Jaffal c a faculty of allied medical sciences, alahliyya amman university, 19328 amman, jordan b faculty of pharmacy, alahliyya amman university, 19328 amman, jordan. We reported that the daily administration of cortisone, aspirin, or indomethacin to rats with this ulcer for 1. Pdf gastroprotective effects of betanin against ethanol. Influence of gender difference and gastritis on gastric. Manassantin a, a neolignan isolated from saururus chinensis, is a major phytochemical compound that has various biological activities, including antiinflammatory, neuroleptic, and human acylcoa.
The effect of oral administration of raw camel milk 5 mlkg b. Introduction of peptic ulcer peptic ulcer is among the most predominant gastrointestinal diseases in the world and is characterized by ulceration in the stomach and duodenum. Jasminum sambac is used in folk medicine as the treatment of many diseases. Gastric ulcer, protective effect, ethanol falcaria vulgaris locally named ghazzyaghi poghazeh is a member of umbelliferae family which grows near farmlands and is. Antioxidative and antiinflammatory effects of water. Gastric ulcer is one of the major gastrointestinal disorders, which occurs due to an imbalance between the offensive gastric acid secretion and defensive gastric mucosal integrity factors1, 2. Gastric ulcer is a chronic disease and serious health issue. Phycobiliproteins of arthrospira spirulina maxima have attracted attention because of their potential therapeutic antioxidant properties. African journal of biotechnology effects of ethanol. Gastric lesions induced by ethanol cytoprotection studies. Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood. Prevention of hclethanol induced gastric mucosal injury.
To explore the possible mechanisms of action, we examined antioxidant defense enzymes e. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and. The differences in gastric lesions between the thomsonide group or teprenone group and the vehicletreated group were not significant, although these lesions were barely reduced by thomsonide or. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Diosmin lowers ulcer index a and area of gastric lesions b in rats with ethanolinduced gastric injury. Ethanol induced gastric damage showed gross mucosal lesion, including long haemorrhage bands and petechial lesion. At creative biolabs, we offer ethanolinduced gastric ulcer models induced in both rats and mice.
Mechanistic evaluation of gastroprotective effects of. Celosia trigyna is a medicinal plant used traditionally for wound healing. The oral administration of hclethanol solution produced characteristic lesions in the glandular portion of the negative control rat stomach with a total surface area of 236. In this study, we determine the cytotoxic, antioxidant and gastroprotective effect of ethab against ethanolinduced gastric mucosal ulcer in rats. Protective effect of falcaria vulgaris extract on ethanol. Sd rats are divided as normal, ulcer control 5 mlkg of 10% tween 20, testing 10 and 20 mgkg of cnbp and reference groups omeprazole 20 mgkg. Oral administration of ethanol extract of the rhizome ofpirorhiza kurroa at a dose of 20mgkg body weight, for 10 consecutive days, was found to enhance the rate of healing on indomethacininduced gastric ulcer in rats, compared to the ulcerated group without treatment. The present study investigated protective effect of zataria multiflora essential oil on ethanolinduced gastric ulcer in rats along with its possible mechanisms. Forty adult wistar rats of either sex were marked, weighed and randomly assorted into 5 groups ae with each group containing 8 rats. The present study was undertaken in rats to evaluate for any antiulcerogenic properties from the aqueous extracts of p. Antiulcerogenic effects of celosia trigyna plant extracts. Gastroprotective activity of ethyl43,5ditertbutyl2.
This study is aimed to evaluate the effect of zingerone on ethanol induced gastric ulcers in rats. Diosmin protects against ethanolinduced gastric injury in. Ethanolinduced gu in animal model resembles the pathophysiology of human ulcer. Ethanolinduced gastric ulcer in rats and intervention of. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of j. Gastric ulcers affect many people around the world and their development is. Pdf gastroprotective effect of zingerone on ethanol. Acute gastritis or gastric ulcer was induced in the rat stomach by 80% ethanol or 60% acetic acid, respectively. Animals pretreated with ethanolic extract of pergularia daemia and standard. Evaluation of anti ulcer activity of ethanolic extract of. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea. Histological analyses and studies of antioxidant and antiinflammatory activities were.
The aqueous extract of piptadeniastrum africanum produced a dosedependent inhibition of gastric ulceration ranging from 81. Gastroprotective effects of ascaridole on gastric ulcer in. This study aimed to isolate the bioactive compounds from celosia trigyna and to investigate the in vitro and in vivo antiulcerogenic effects of the extracts on ethanolinduced gastric ulcer on adult wistar rats to determine their. The ulcer index parameter was used for the evaluation of ulcer activity. Within 1 min of contact, ethanol caused diffuse mucosal hyperemia. By 5 min, hyperemia greatly intensified at some mucosal sites. The results obtained show that the ulceration in gastric linings of the stomach of rats pretreated with the c. Antioxidant activity of ethanol extract of rhizome of. Its therapeutic properties suggest its alternative use in the treatment of various ailments and illnesses. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. The gastro protective effects of cibotium barometz hair on. Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced. The present study was designed to evaluate the antiulcer activity of plant in ethanol induced gastric ulcer.
Gastric ulcers were induced in sprague dawley rats using one oral dose of absolute ethanol 1. The animals were sacrificed after 4 hr and functional indices of ulcer activity was studied in all rats and compared with that of nonulcer induced ones. This study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. The aim of this study was assessment the antiulcer effects of c. Administration of ethanolic extract of aegle marmelos and standard drug omeprazole both produced highly significant p rats hassan z. To evaluate the antiulcer activity of caesalpinia pulcherrima on ethanol induced gastric lesion in albino rat. Zingerone is an ingredient of ginger zingiber officinale with different pharmacological activities. Studies on the mechanism of ethanolinduced gastric damage. Antiulcer activities of the ethanol extract of cissus quadrangularis roots on indomethacin and ethanolinduced gastric ulcers were investigated. Author links open overlay panel kandhasamy sowndhararajan sun chul kang. The ethanolinduced ulcer model in rats or mice still remains one of the most used method in the. Millergastric injury induced by ethanol and ischemiareperfusion in the rat.
Wister albino rats were selected and divided into five groups. Biochanin a gastroprotective effects in ethanolinduced. Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress induced ulcer in rats author links open overlay panel yifeng zheng a 1 jianhui xie a b 1 yifei xu a 1 yongzhuo liang a zhizhun mo a weiwen jiang a xiaoying chen a yuhong liu a xiaodan yu a ping huang a c ziren su a c. Protective role of phoenix dactylifera fruit against. Gastroprotective effect of zingerone on ethanolinduced.
Effects of pithecellobium jiringa ethanol extract against. The level of peroxidised lipid, in terms of thiobarbituric acid reactive species tbars, in gastric tissue, was. Protective effect of ethyl acetate fraction of acacia. Pdf gastroprotective effects of pistacia atlantica extract on. Delayed healing of acetic acidinduced gastric ulcers in. Gastroprotective activity of a novel schiff base derived. Therapeutic effect of momordica balsamina leaf extract on.
Gastric ulcers were induced by oral ingestion of ethanol. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, ado. A doseeffect relation was constructed using the ethanolinduced gastric ulcer model in male wistar rats. The rats were fasted for 24 h, the separate groups. We have investigated this mechanism in the rat stomach via gross morphologic, videomicroscopic, histochemical, and pharmacologic approaches. Normal saline and ranitidine were used as negative and positive control. Protective effect of ethyl acetate fraction of acacia ferruginea dc.
Pdf antiulcerogenic effect of cuphea ignea extract. Current antigastric ulcer agents have side effects, despite the progression and expansion of advances in treatment. Mechanisms of gastroprotective effects of ethanolic leaf. Protective effects of manassantin a against ethanol. Taken together, the findings of this research amply demonstrated that weac exerted appreciable gastroprotective effect against ethanolinduced gastric ulcer in rats. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Cibotium barometz is a medical herb used traditionally in the malaysian peninsula for several ailments, including gastric ulcer.
Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male. Physiological saline and lansoprazole were used as negative and positive control, respectively. Antiulcerogenic effect of camel milk against ethanol. Ethanol causes necrotic lesions that reduce gastrointestinal tract defensive factors like bicarbonate secretion and the production of mucus and its circulation 2224. Except for the normal group, the rest of the groups are induced gastric ulcer by ethanol 1 h after the pretreatment. Anti ulcer and antioxidant activity of moringa oleifera lam leaves against aspirin and ethanol induced gastric ulcer in rats vinay kumar verma, nripendra singh 1, puja saxena and ritu singh assistant professor, department of pharmacy, v. Pdf 2981 k pdf plus 488 k gastroprotective activity of loranthus acaciae flower extract in a rodent model of ethanolinduced ulcer. In this study, we investigated the protective effects of manassantin a against ethanolinduced acute gastric injury in rats. Pdf amelioration of ethanolinduced gastric ulcers in rats. Amelioration of ethanolinduced gastric ulcers in rats pretreated.
This agent is also effective as mucosal protection in treatment of nonacid depended models such as ethanol induced ulcer model 3, 7, 30. Gastric ulceration was induced using 80% ethanol after a pilot study was done to identify which ulcer inducing agents. Gastroprotective effect of phyllanthus niruri leaf extract. Research paper ulcer prevention effect of 3,4,5tihydroxy. Gastroprotective effects of ascaridole on gastric ulcer in rats. Amelioration of ethanolinduced gastric ulcers in rats.
Vanillin abrogates ethanol induced gastric injury in rats via. Antiulcer and antioxidant activity of moringa oleifera. Gastroprotective activity of loranthus acaciae flower. Research article ethanolinduced gastric ulcer in male. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of. The incidence of peptic ulcer is increased due to stress, smoking, alcohol, helicobacter pylori and ingestion of nonsteroidal antiinflammatory drugs nsaid 3, 4, 5. Gastroprotective effect of gallic acid against ethanol. Pdf phycobiliproteins of arthrospira spirulina maxima have attracted attention because of their. Table 1 shows the effect of ethanol extract of this plant on ulcer index, gastric glutathione and alp activity. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal group, cmc as ulcer group, 20 mgkg of omeprazole. Gastroprotective effect and mechanism of patchouli alcohol.
After the treatment period, rats received oral administration of 1. Thus, the current study aimed to investigate the potential protective effects of dio against ethanolinduced gastric injury in rats. The ethanol extract of cardiospermum halicacabum in a concentration dependant manner exhibited marked gastro protection in ethanol induced ulcer model. Effect of cardiospermum halicacabum on ethanolinduced. This study aimed to investigate the gastroprotective. Ethanolinduced rodent gastric ulcer model creative biolabs. To investigate the protective effects of berberine on ethanolinduced gastric ulcer in mice. Administration with weac not only markedly increased the activities of cat, sod, and gsh, decreased the level of mda, but also reduced the productions of tnf.
Protective role of phoenix dactylifera fruit against ethanolinduced gastric ulcer in wistar rats background. Antiulcerogenic activity of scutia buxifolia on gastric. Eighty male adult rats were randomly allocated into 8 groups as follows. Central ghrelin 44000 ngrat dosedependently reduced ethanolinduced gastric ulcers by 3977%. Gastroprotective effects of betanin against ethanolinduced gastric ulcer in rats article pdf available in jundishapur journal of natural pharmaceutical products in pressin press july 2019. Antiulcerogenic effect of cuphea ignea extract against ethanol. Rats were killed either with gastritis alone or thereafter at day 1, 3 or 6 after ulcer induction. The anti ulcer study was evaluated using ethanol induced gastric ulcer in rats. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanolinduced gastric ulcers in rats.
Gastric ulcer was induced in overnight fasted rats that. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced by ethanol in rats. Diosmin attenuates gastric histopathologic aberrations and influx of leukocytes the current study next explored whether dio can protect against the histopathologic damage associated with ethanolinduced gastric injury in rats. Ghrelin protects against ethanolinduced gastric ulcers in. Roles of nitric oxide in protective effect of berberine in. There were no reports regarding the gastroprotective activity of p.
Materials and methods omeprazole omeprazole is a class of drugs called proton pump inhibitors used. Conventional histology and immunohistochemistry for ghrelin, gastrin, and somatostatin were performed on gastric specimens from representative rats. The ethanolinduced gastric lesions in the indomethacinpretreated rats measured 79. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat. The present study was designed to investigate the cytoprotective and antiinflammatory properties of tertbutylhydroquinone tbhq, a nuclear factor erythroid 2related factor 2 nrf2 activator, against gastric mucosal damage induced by acute exposure of ethanol. The concentrations of drug were prepared in such a way that each rat.
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